Cisdiamminedichloroplatinum

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WebMay 15, 2015 · The interest in gold(III) as anticancer agent is a result of the current significance of the anticancer cisplatin, cis-diamminedichloroplatinum(II), [PtCl 2 (NH 3) 2] . Although cisplatin has been used for a long time for the treatment of different types of cancer there are several limitations and drawbacks. Gold(III) compounds provided ... Weba platinum coordination compound whose main mode of action resembles that of alkylating agents with production of cross links between the two strands of DNA in the double helix …

Spectrum of cis-diamminedichloroplatinum(II)-induced …

WebApr 20, 2016 · miR-3188 suppresses cell growth and 5-FU chemoresistance. To identify the role of miR-3188 in NPC development, we first examined its expression levels in normal epithelium (NP) and NPC cell lines. miR-3188 expression was elevated in NP69 and SXSW-1489 cells but weakly expressed in NPC cells (Fig. 1a).To further explore its biological … WebAbstract Cis-diamminedichloroplatinum (DDP) was used as the initial treatment in a pilot study of 17 patients with biopsy-proven transitional cell carcinoma of the bladder. No … phineas and ferb teenagers

Diamminedichloroplatinum - an overview ScienceDirect Topics

WebMar 1, 1979 · 1. Cisplatin is a co-ordination complex of a central platinum atom, two chlordies and two ammonia molecules in the “ cis ” position. 2. A prime mechanism of … WebCisplatin Cl2H6N2Pt CID 5460033 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety ... WebCisplatin (cis-diamminedichloroplatinum) is an alkylating agent and a subset of platinum (II) analogs. It acts by producing an immensely reactive moiety that facilitates the cross … phineas and ferb teenage episode

cis-Diamminedichloroplatinum in the treatment of advanced …

Cisplatin (cis-diamminedichloroplatinum II) - ScienceDirect

WebCis-diamminedichloroplatinum (II)-induced acute renal failure in the rat. Correlation of structural and functional alterations T. W. Jones, S. Chopra, J. S. Kaufman, W. … WebCisplatin (cisdiamminedichloroplatinum) for treatment of transitional cell carcinoma of the urinary bladder or urethra. J Vet Intern Med. May-Jun 1990;4(3):148-52.doi: 10.1111/j.1939-1676.1990.tb00888.x. Authors A S Moore 1 , A Cardona, W … tso c64bWebCisplatin (cisplatinum, cis-diamminedichloroplatinum II, CDDP) is an inorganic platinum complex, which is able to inhibit DNA synthesis by conforming DNA adducts in tumor cells. Cisplatin activates ferroptosis and induces autophagy. Solutions are best fresh-prepared. Catalog No. NC0564900 $86.10 / Each of 1 Qty Check Availability Add to cart tso-c63e

"WebDec 3, 1979 · [Cis-diamminedichloroplatinum(II). A new antineoplastic agent derived from the group of heavy metal complexes (author's transl)] Platinum coordination complexes represent a new class of antineoplastic agents among which only cis-diamminedichloroplatinum(II) (cis-DDP) has undergone extensive clinical trials. " - Cisdiamminedichloroplatinum

Cisdiamminedichloroplatinum

Webcis-Diamminedichloroplatinum(II): effects of a representative metal coordination complex on mammalian cells Pharmacol Ther. 1984;25(3):297-326.doi: 10.1016/0163 … Webcis-Diamminedichloroplatinum (II) induced distortion in a double-helical DNA fragment jeroen den hartog 1984, Journal of The American Chemical Society Download Free PDF Related Papers Journal of the … Mechanism of two-electron oxidation of deoxyguanosine 5'-monophosphate by a platinum (IV) complex 2004 • Amanda Hakemian Download Free …

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WebA total of 26 patients with biopsy proved epidermoid carcinoma of the penis (Jackson stage III or IV) with measurable disease, no prior chemotherapy and adequate renal function …

WebJun 1, 1973 · cis -Diamminedichloroplatinum (II) is the first of a group of platinum coordination complexes with antineoplastic activity to be studied in humans. This Phase I investigation characterizes the toxicity and pharmacological disposition of … WebCisplatin (cis-diamminedichloroplatinum II) Cisplatin (cis-diamminedichloroplatinum II) Cisplatin (cis-diamminedichloroplatinum II) Cancer Treat Rev. 1979 Mar;6(1):17-39. doi: …

WebCisplatin (cis-Diamminedichloroplatinum) is a organometallic compound and one of several platinum-based antineoplastic agents used in certain types of chemotherapy for the treatment of cancer. These compounds, … Webcis-Diamminedichloroplatinum(II): effects of a representative metal coordination complex on mammalian cells Pharmacol Ther. 1984;25(3):297-326.doi: 10.1016/0163-7258(84)90003-2. Author E B Douple PMID: 6542679 DOI: 10.1016/0163-7258(84)90003-2 No abstract available Publication types

WebJul 4, 1995 · The combination of cis-diamminedichloroplatinum(II) (CDDP) and 7-ethyl-10-[4-(I -piperidino)-I -piperidino]carbonyloxycamptothecin (CPT-I I), a topoisomerase-l inhibitor, has been shown to be synergistic in vitro and clinically active against several human cancers refractory to chemotherapy. To elucidate the mechanism of the …

WebSep 24, 2024 · Cisplatin (CDDP) is the drug of choice against different types of cancer. However, tumor cells can acquire resistance to the damage caused by cisplatin, generating genetic and epigenetic changes that lead to the generation of resistance and the activation of intrinsic resistance mechanisms in cancer cells. Among them, we can find mutations, … tso-c66cWebCis-diamminedichloroplatinum (II) (DDP) leads the series of platinum coordination complexes, a new class of cytotoxic agents. The antitumor and toxic effects of this drug … tso c63fWebThree Co(III) complexes of a designed ligand PMAH that mimics the metal-binding domain of the antitumor antibiotic bleomycin (BLM) have been isolated and structurally characterized. The coordination tso c66cWebtrans-Platinum(II) diamminedichloride Cl2H6N2Pt+2 CID 441203 - structure, chemical names, physical and chemical properties, classification, patents, literature ... tso-c63cWebA comparative study was performed with a variety of human cell lines on the effects of treatments with cis-diamminedichloroplatinum (II) (cisplatin) on cell survival and the induction of unscheduled DNA synthesis. tso c72bWebA docetaxel-resistant prostate cell line (PC3DR2) was subsequently established using the same method (9); resistance-associated genes in this cell line were examined in the present study through DNA microarray, western blot analysis and reverse transcription-quantitative polymerase chain reaction (RT-qPCR). tso-c64aWebThe thioredoxin (TRX) system, composed of nicotinamide adenine dinucleotide phosphate (reduced form), TRX, and TRX reductase (TRXR), has multiple biologic functions via thiol-mediated redox control. In this study, we investigated the relationship between intracellular TRXR levels and cellular sensitivity to cis-diamminedichloroplatinum (II) (CDDP). tso c66