Cisplatin mitochondria

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August undefined, 2024

WebNext, synergistic effect of cisplatin combined with ZD55-MnSOD on ovarian cancer cell SKOV-3 was quantified by combination index (CIN) analysis and expressed as CIN versus fraction affected in Figure 2B. These results showed that the combination of cisplatin and ZD55-MnSOD has an enhanced tumor killing effect. WebJan 9, 2024 · Cancer Drug 49 Times More Potent than Cisplatin ... business news

Precisely Assembled Nanoparticles against Cisplatin Resistance via ...

WebMay 10, 2024 · Cisplatin is a platinum-based chemotherapeutic that damages genomic DNA leading to cell death. It also damages mitochondrial DNA and induces high levels of mitochondrial reactive oxygen species (mtROS), further sensitising cells to apoptosis. Notably, immature oocytes are particularly vulnerable to cisplatin treatment, a common … WebJul 5, 2024 · Mitophagy is an autophagic procedure that specifically clears damaged mitochondria and maintains its homeostasis. Emerging evidence indicates that mitophagy is involved in many physiological processes, including cellular homeostasis, cellular differentiation and nerve protection. churches in itasca il

VDAC1 as a target in cisplatin anti-tumor activity through …

WebNational Center for Biotechnology Information WebJul 10, 2024 · Cisplatin is one of the worldwide anticancer drugs and, despite its toxicity and frequent recurrence of resistance phenomena, it still remains the only therapeutic … WebNational Center for Biotechnology Information development and progress difference

Metformin potentiates the anticancer effects of cisplatin under ...

Mitochondrial DNA alterations may influence the cisplatin ... - Nature

WebOct 29, 2024 · Cisplatin induced mtDNA leakage into the cytosol-probably through BCL-2-like protein 4 (BAX) pores in the mitochondrial outer membrane-in tubules, with subsequent activation of the cGAS-STING... WebJun 10, 2024 · NUS chemists have developed a mitochondria-targeted fluorescent probe for real-time imaging of clinically important anticancer drug cisplatin in live cancer cell … development and planning commission gibraltarWebJul 6, 2016 · Cisplatin (cis diamminedichloroplatinum II, cDDP) is one of the most effective cancer chemotherapeutic agents and is used in the treatment of many types of human malignancies. However, inherent tumour resistance is a major barrier to effective cisplatin therapy. So far, the mechanism of cDDP resistance has not been well defined. churches in jacksonville fl

"WebMay 12, 2024 · Cis -diamminedichloroplatinum (II), or cisplatin, is one of the most commonly used chemotherapy agents in the treatment of various solid tumours such as … " - Cisplatin mitochondria

Cisplatin mitochondria

Cisplatin induced mitochondrial DNA damage in dorsal root …

WebAug 6, 2015 · The foremost reason of cisplatin-related cytotoxicity has been correlated to the generation of mitochondrial reactive oxygen species (ROS) that influence multiple … WebApr 11, 2024 · Introduction. Ovarian cancer (OC) is a lethal gynecological malignancy. Most OC patients benefit from initial treatments with cytoreductive surgery followed by cisplatin (CP)-based chemotherapy 1.However, approximately 70% of OC patients relapse and develop drug-resistance after long-term use of CP 2.Multilayer alterations have been …

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WebThe additive effects of metformin on cisplatin-induced inhibition of cell proliferation were attenuated under hypoxic conditions, while metformin compromised mitochondrial structure and function. Additional studies are needed to determine the efficacy of this drug combination in vivo. Publication types Research Support, Non-U.S. Gov't MeSH terms WebOct 13, 2024 · Cisplatin also disrupts mitochondrial biogenesis, as indicated by reduced renal expression of the master regulator of mitochondrial biogenesis PPARG coactivator 1 alpha (PPARGC1A, also known...

WebMitochondria do not have NER mechanisms for mtDNA. We demonstrate that cisplatin forms adducts with mtDNA in DRG neurons, and that this alters mtDNA replication and transcription. The resultant cisplatin-induced mitochondrial dysfunction may lead to a novel mechanism of cisplatin neurotoxicity. WebNational Center for Biotechnology Information

WebApr 23, 2024 · Cisplatin / toxicity Drugs, Chinese Herbal / therapeutic use* Humans Hyperalgesia / chemically induced Hyperalgesia / drug therapy Membrane Potential, Mitochondrial / drug effects Mice Neurotoxicity Syndromes Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha / metabolism Drugs, Chinese Herbal WebKey results: We demonstrated that the prominent mitochondrial fragmentation occurred in experimental models of cisplatin-induced nephrotoxicity, which was coupled to radical oxygen species (ROS) overproduction, deterioration of mitochondrial function, release of apoptogenic factors and the consequent apoptosis.

WebNov 7, 2024 · Cisplatin binds to DNA and induces DNA-damage culminating in mitochondria-mediated apoptosis. Interestingly, mitochondrial DNA is critically affected by cisplatin but its relevance in cell...

WebA study in Chinese hamster ovary cells demonstrated that the proportion of adducts of cisplatin on mitochondrial DNA was four to six times higher compared to nuclear DNA by dissociation-enhanced lanthanide fluoroimmunoassay (DELFIA) and immunoelectron microscopy (Olivero et al., 1995; Jamieson and Lippard, 1999). churches in jacksonville alabamaWebAims: This study investigated the regulatory effect of Mitofusin2 (Mfn2) on mitochondria-associated endoplasmic reticulum membrane (MAMs) integrity and cellular injury in cisplatin-induced acute kidney injury (CP-AKI). Results: CP- AKI mice exhibited decreased expression of Mfn2, increased expression of phosphorylated adenosine monophosphate … churches in jacksonville texasWebSep 30, 2024 · Cisplatin resistance in tumor cells is known mainly due to the reduced accumulation of platinum ions by efflux, detoxification by intracellular GSH, and nucleotide excision repair machinery-mediated nuclear DNA repair. In this work, theranostic Pt(IV)-NPs, which are precisely self-assembled b … churches in jackson wisconsinWebmaintaining mitochondrial number and function is dem-onstrated by studies showing that the maturation of oo-cytes is severely impaired when mitochondrial activities are sub-optimal [26, 27]. Cisplatin is known to damage the DNA of oocytes, but the possibility that cisplatin also compromises oocyte survival and quality by damaging mitochondria ... development and promotionsWebJun 30, 2024 · The novel aspect of our work suggested that cisplatin not only induces mitochondrial oxidative damage by attacking DNA and proteins in cancer cells, but also restrain mitochondria self-renewal by inhibiting mitochondrial fission and mitophagy, which lead to damaged mitochondrial accumulation. churches in jackson wyWebMay 12, 2024 · Cis -diamminedichloroplatinum (II), or cisplatin, is one of the most commonly used chemotherapy agents in the treatment of various solid tumours such as ovarian, colorectal, prostate, lung, and... churches in jacksonville beach flWebFeb 11, 2015 · cisplatin mitochondria imaging Supporting Information Details of chemical synthesis, structural analysis, and biological assays. This material is available free of … churches in jaffrey nh