WebApr 19, 2024 · RT, despite the advanced disease, survival was comparable to the combination of cisplatin Vet. Sci. 2024 , 9 , 196 9 of 47 and piroxicam as well as intralesional cisplatin implant, of which the ... WebAim of the study: To define the maximum tolerated dose (MTD) and toxicity of trabectedin (T) and cisplatin (C) given on days 1 and 8 every 3 weeks to adult patients with advanced solid tumours.
Phase I pharmacokinetic study of S-1 plus cisplatin in ... - PubMed
WebJun 16, 2024 · The DD regimen was defined as the combination of 5 mg/kg paclitaxel and 3 mg/kg cisplatin, while the MTD regimen consisted of higher dosages of 12 mg/kg paclitaxel and 7 mg/kg cisplatin. These results clearly showed that DD chemotherapy profoundly reduced the number of MDSCs, more significantly than mice in the MTD group. ... WebDec 1, 2024 · A cisplatin-derived Pt (IV) prodrug was conjugated to 2- (1-methyl-1,2,3,6-tetrahydropyridin-4-yl)propenamide to target GBM mitochondria, showing promising anti-tumoral effects in vitro and in vivo [ 31 ]. Low intensity pulsed ultrasound increases carboplatin delivery across the BBB by 4.2-fold and increased survival in GBM murine … ects note a
Maximum Tolerated Dose, Safety and Efficacy of Docetaxel / Cisplatin ...
WebJul 20, 2024 · This regimen, also known as “medium dose intermittent cyclophosphamide” (MEDIC), has been shown to have potent immunostimulatory effects on natural killer (NK) cells and also result in development... WebA treatment cycle consisted of cisplatin on day one, followed by thermal therapy and simultaneous gemcitabine 36 hours later; then a second dose of gemcitabine one week later; and daily IFN- α. Results: Thirty-seven patients were treated on protocol. The MTD of cisplatin in the thermochemotherapy regimen was established to be 60 mg/m 2. The ... WebCisplatin-eligible subjects will receive pembrolizumab at starting dose of 200mg (dose level 0), and/or 120mg (dose level -1) in combination with gemcitabine and cisplatin. The MTD will be the highest pembrolizumab dose level in combination with gemcitabine/cisplatin every 21 days, repeated for 4 cycles. ects polsl