WebApr 15, 2024 · During drug development, potential compounds may exhibit unexpected nephrotoxic effects, which imposes a significant financial burden on pharmaceutical … Webdamage to the heart muscle inflammation around the drip site sore eyes tummy (abdominal) pain heart failure (build up of fluid in the body) skin rash and itching Rare side effects …
Doxorubicin: MedlinePlus Drug Information
WebMar 14, 2024 · Doxorubicin may cause dangerous effects on your heart. Call your doctor at once if you feel very weak or tired, or have fast heartbeats, shortness of breath (even with … WebFeb 1, 2024 · Doxorubicin (DOX) is a highly effective antineoplastic agent used in cancer treatment. Unfortunately, clinical use of DOX is limited due to the development of dose-dependent toxicity to cardiac and respiratory (i.e., diaphragm) muscles. ... Heart / drug effects Mitochondria, Heart / metabolism Mitochondria, Muscle / drug effects ... chilly reich
Doxorubicin (Adriamycin, Rubex) OncoLink
Late damage to the heart starts about a year or more after chemotherapy. Doxorubicin mainly affects the heart muscles. It weakens the heart muscles and makes the pumping of blood more difficult for the heart. When severe, it leads to a condition called congestive heart failure (CHF). Individuals with … See more Doxorubicin (trade name Adriamycin) is a commonly used chemotherapy agent that is very effective in both Hodgkin and Non-Hodgkin lymphomas. It is used in virtually all the first-line … See more Heart damage is usually tested with an echocardiogram (commonly called an 'echo') or a MUGA scan to test for the amount of blood that … See more It is well recognized that doxorubicin may cause damage to the heart in some individuals. While other anthracyclines (like epirubicin and … See more Doxorubicin reacts with some chemicals in the body (called enzymes) to produce harmful substances called free radicals. The production of these harmful free radicals is enhanced … See more WebDespite its effectiveness, cardiotoxicity is a major late effect that compromises the survival and quality of life of survivors of this and other cancers. Cardiotoxicity is the inability of the heart to pump blood through the body effectively. … WebDoxorubicin can be toxic to the heart and cause heart damage which can appear years after treatment has ended 1. Because of this toxicity, there is a lifetime maximum dose of doxorubicin 1. Before you start treatment with this drug, your heart function will be evaluated, and while you are on treatment, your cardiac functioning will be monitored. chilly response